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Mucuna Pruriens – Improved Testosterone and FertilityMucuna Pruriens – Improved Testosterone and Fertility

Mucuna Pruriens is associated with an improved male fertility (increase in testosterone and its precursors). Moreover, it can relieve the symptoms of Parkinson’s disease

What is Mucuna Pruriens?

It is a leguminous plant that grows in tropical climates

In fact, this plant is used to produce food supplements. Even though these products are sold as “Mucuna Pruriens”, they are actually and extract obtained from the seeds of this plant. This is where the active ingredients of the plant are.

Properties of Mucuna Pruriens

Traditionally, the Mucuna Pruriens has been used for its aphrodisiac and invigorating properties.

Particularly, this is due the fact that the seeds contain a high percentage of L-Dopa. Said amino acid is a precursor form of the neurotransmitter Dopamine. Above all, it performs many physiological functions (sleep control, mood, cognition, reward and addiction system, catecholaminergic, lactation…).

Man modelling

Therefore, Mucuna Pruriens is a powerful dopaminergic substance used to increase the dopamine levels.

Although not all the positive effects of Mucuna are on the dopaminergic system, but most of them are

What are the uses of Mucuna Pruriens?

Despite the fact that Mucuna has many physiological effects proven in human and animals, we will review two of the main properties of this substance in this article:

  • Increasing the fertility (more testosterone and precursors)
  • Buffering the symptoms of Parkinson

Moreover, there is a stronger evidence in humans regarding these effects. Both the consistency and results are solid enough to conclude that it truly works.

Mucuna Pruriens and Male Fertility

Above all, Mucuna Pruriens has been widely used to improve the fertility of men

This compound seems to improve the fertility by increasing the volume of ejaculate; density of spermatozoa (spermatogenesis); apart from improving their motility.

That is, it is a useful product to treat the 3 main pathologies caused by male infertility:

  1. Hypospermia (low volume of semen).
  2. Oligospermia (low number of spermatozoa in the semen).
  3. Asthenospermia (hypomotility of the spermatozoa present in the ejaculate; regardless of the amount).

Study 1

Shukla et al. (2009) conducted a study in which the participants took 5g of a Mucuna Pruriens seed extract supplement a day in a single dose.

Above all, it improved the amount of ejaculate, the % of motility of the spermatozoa and their amount. Not just for those who suffer Oligospermia or Asthenospermia, but also for those who are Normospermic.

A couple

In other words, subjects who do not suffer alterations in the sperm.

All in all, if you want to improve your fertility, 5g/day of Mucuna Pruriens extract could be enough, regardless of your conditions

Study 2

The authors that we mentioned previously also participated in a later study by Gupta et al. (2011). In fact, they used the same dose once again (5g/day) in normospermic, oligospermic and asthernospermic subjects.

Once again, they reached the same conclusions, Mucuna improves the fertility of the subjects regardless of their conditions. But in this case they also measured the lipid peroxidation of the semen.

In short, the lipid peroxidation is a process through which the EROs and ERHs damage the cell membrane. Although a “mild peroxidation can stimulate and activate the spermatozoa” (Membrillo et al., 2003)

However, an excessive peroxidation can damage the sperm (Gadella et al. 2001, quoted in Membrillo et al., 2003). Consequently, buffering said process will improve the functionality of the spermatozoa and, in turn, the fertility.

Conclusions

The study also included an analysis of the different amino acid concentrations in the semen of the subjects through nuclear magnetic resonance spectroscopy.

Finally, the authors concluded that taking 5g of Mucuna Pruriens daily considerably improved the metabolic profile of the amino acids from the seminal plasma.

We do not exactly know the role of each amino acid on fertility. Moreover, the etiology of their concentration (eu- or dis-) is quite different. We just want to clarify that a proper balance of the metabolite spectrum from the different amino acids in semen will determine the degree of male fertility.

All in all, Mucuna Pruriens is an useful substance when it comes to improving the fertility of male subjects

Mucuna Pruriens and Testosterone

Moreover, the authors conclude that this substance improves the male fertility through several ways that condition it. For example, one of them is the hormone balance, something many people are interested in.

In fact, I am sure that many are thinking: “But if Mucuna Pruriens improves the fertility, does it also increase the testosterone?” YES, it does

How does it increase the Testosterone?

Above all, Mucuna Pruriens improves the hormone balance that depends on the HPTA:

  • It increases the LH (luteinizing hormone) and T (Testosterone)
  • Then, it reduces the FSH (follicle stimulant hormone) and PRL (prolactin)

In fact, these results are the same in several essays and with an interesting increase magnitude in subjects from all groups):

GROUP
MARKER Oligospermia Normospermia Asthenospermia
T +39% +27% +17%
LH +41% +23% +40%

Chart I. Changes in the Testosterone (T) and Luteinizing Hormone (LH) concentrations from different groups after taking 5g/day of Mucuna Pruriens for 3 months. taken from Shukla et al. (2009)

Moreover, the FSH and PRL drops were not calculated in % in the study. However, the pre and post-treatment reductions have been significant for all groups

Explanation

The action mechanism of Mucuna seems to improve the hormone environment due to the L-Dopa content from its seeds. In addition, it contains catecholamin active metabolites (epinephrine, norepinephrine and dopamine):

  • L-Dopa crosses the BBB (Brain Blood Barrier) and increases the dopamine levels in the brain. Therefore, this inhibits the production of PRL in the anterior lobe of the pituitary gland.
  • Then, this stimulates the production of GnRH in the hypothalamus.
  • GnRH is the gonadotropin, a signalling stimulant of the LH production by the pituitary gland.
  • At the same time, LH travels to the gonads (testicles) where the Leydig cell receptors increase the cAMP production from ATP. Consequently, this stimulates the Testosterone production.

Improved hormone homeostasis

All of us have heard about products that increase the serum testosterone, which inhibits the LH production by negative feedback, right?.

But Mucuna Pruriens is a very interesting supplement to recover the hormone homeostasis of those who have used this products.

Blood serum clinical variables

Figure I. Changes in the pre- and post-treatment serum concentrations of LH, FSH, T and PRL of infertile subjects that belong to normospermic, oligospermic and asthenospermic groups when compared to the control group.(Gupta et al., 2011)

Likewise, taking 0.5g of L-Dopa orally seems to significantly increase the growth hormone levels of healthy subjects. According to the information gathered by Chiara et al. (1986).

However, we would need a lot of Mucuna Pruriens to reach that amount of L-Dopa. Therefore, it would not be interesting to use this kind of supplementation for that purpose, or we would have to add extra doses.

Mucuna Pruriens and Parkinson

Finally, we also wanted to mention is its potential to treat Parkinson.

This progressive neurodegenerative disease destroys the presynaptic neurons located in the black matter. Therefore, it significantly lowers the synthesis of dopamine.

Above all, people use a palliative treatment to slow down the symptoms of this disease, a combination of Levodopa and Carbidopa. However, Mucuna Pruriens seems to be more effective than the traditional treatment with Levodopa and Carbidopa. In fact, it increases the plasma dopamine levels sooner and more efficiently.

Plasma L-Dopa concentration

Figure II. Plasma concentration (axis Y) in time (axis X) after taking 200mg of Levodopa+50mg from carbidopa (rhombus), 15g of Mucuna Pruriens seed powder (square) and 30g of Mucuna Pruriens seed powder (triangle). (Katzenschlager et al., 2004)

Study

Katzenschlager et al. (2004) showed how taking 15g (500mg of L-Dopa) and 30g (1000mg of L-Dopa) of Mucuna Pruriens was more effective than taking 200mg of Levodopa + 50mg of Carbidopa

Particularly, taking 30g of Mucuna Pruriens produced a peak that was a 110% superior to the combination of levodopa+carbidopa. In fact, its area under the curve was a 165.3% higher and it lasted an average of more 37 minutes (21.9%) than the traditional treatment.

However, despite the good response of the subjects, without reported toxicity or side effects, the dose of Mucuna Pruriens was extremely high.

We suggest consulting a neurologist before using these doses of Mucuna Pruriens, since this article does not replace medical advice by any means. Alfredo Valdés is not responsible for the use of the academic information from this article.

Maximum Dose

The AECOSAN (Spanish Agency for Consumer Affairs) concluded that the maximum dose (tested on animals) was 70mg/kg/day; and this maximum dose became toxic due to the neurotoxic effects of L-Dopa.

On the contrary, the lowest toxic dose for oral L-Dopa in humans is 4286mg/kg. However, we still need to be cautious, since Mucuna Pruriens does not only contain this substance.

Despite all this, do not exceed the recommended daily dose by any means, unless if you are under medical supervision. Above all, the safest dose seems to be 30g since it does not cause side effects (AECOSAN, 2016).

Bibliography

  1. Membrillo Ortega, A., Córdova-Izquierdo, A., José Hicks Gómez, J., Olivares-Corichi, I., Manuel Martínez Torres, V., & de Jesús Valencia Méndez, J. (2003). Peroxidación lipídica y antioxidantes en la preservación de semen: Una revisión. Interciencia, 28, 699–704.
  2. Chihara, K., Kashio, Y., Kita, T., Okimura, Y., Kaji, H., Abe, H., & Fujita, T. (1986). L-dopa stimulates release of hypothalamic growth hormone-releasing hormone in humans. The Journal of Clinical Endocrinology and Metabolism, 62(3), 466–473.
  3. Katzenschlager, R., Evans, A., Manson, A., Patsalos, P. N., Ratnaraj, N., Watt, H., … Lees, A. J. (2004). Mucuna pruriens in Parkinson’s disease: a double blind clinical and pharmacological study. Journal of Neurology, Neurosurgery, and Psychiatry, 75(12), 1672–1677.
  4. Shukla, K. K., Mahdi, A. A., Ahmad, M. K., Shankhwar, S. N., Rajender, S., & Jaiswar, S. P. (2009). Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis. Fertility and Sterility, 92(6), 1934–1940.
  5. Gupta, A., Mahdi, A. A., Ahmad, M. K., Shukla, K. K., Bansal, N., Jaiswer, S. P., & Shankhwar, S. N. (2011). A proton NMR study of the effect of Mucuna pruriens on seminal plasma metabolites of infertile males. Journal of Pharmaceutical and Biomedical Analysis, 55(5), 1060–1066.
  6. Santacruz, J. A., Sinovas, M. H., Carras-, M. I., Lorenzo, S. M., Valle, M. Y., Herrera, A. D. M., … Carrasco, M. I. (n.d.). Informe del Comité Científico de la Agencia Española de Consumo , Seguridad Alimentaria y Nutrición ( AECOSAN ) sobre el riesgo del uso de semillas de Mucuna pruriens en productos de artesanía.

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